Increase in body weight after pramipexole treatment in Parkinson's disease
Identifieur interne : 003381 ( Main/Exploration ); précédent : 003380; suivant : 003382Increase in body weight after pramipexole treatment in Parkinson's disease
Auteurs : Hatice Kumru [Espagne] ; Joan Santamaria [Espagne] ; Francesc Valldeoriola [Espagne] ; Maria J. Marti [Espagne] ; Eduardo Tolosa [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Affect (drug effects), Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Benzothiazoles (pharmacology), Benzothiazoles (therapeutic use), Body Mass Index, Body Weight (drug effects), Body weight, Female, Follow-Up Studies, Humans, Male, Middle Aged, Movement (drug effects), Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pramipexole, Severity of Illness Index, Treatment, Weight gain, pramipexole, weight gain.
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Benzothiazoles.
- drug effects : Affect, Body Weight, Movement.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Antiparkinson Agents, Benzothiazoles.
- Aged, Body Mass Index, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS‐III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21086
Affiliations:
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Le document en format XML
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Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS‐III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Kumru, Hatice" sort="Kumru, Hatice" uniqKey="Kumru H" first="Hatice" last="Kumru">Hatice Kumru</name></region><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J." last="Marti">Maria J. Marti</name><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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